The Diagnosis and Management of Haemophilia and Christmas Disease.

Diagnostic difficulties in mild haemophilia and Christmas disease.

Two cases of haemorrhagic diathesis are described, where the laboratory diagnosis was confused owing to previous blood transfusions. Without the help of investigating the relatives, the nephew of Case 1, the haemophiliac, and the uncle of Case 2, with Christmas disease, there would have been considerable delay in reaching the diagnosis and so instituting the correct treatment.

Christmas disease: diagnosis and management of a haemorrhagic diathesis following dentofacial trauma.

Haemorrhagic diathesis has been of much concern to health professionals including dentists. It is not infrequent that a dentist becomes the first person to diagnose a bleeding disorder while performing dental treatment. Haemophilia is an X linked disorder with a frequency of about 1:10,000 births. Haemophilia B is much less common than haemophilia A, and affects only 1:300,000 males born alive....

An investigation of three patients with Christmas disease due to an abnormal type of factor IX.

Three patients with Christmas disease whose plasma was shown to have a prolonged one-stage prothrombin time with ox brain thromboplastin have been investigated. These patients have an inhibitor for the reaction between factor X, factor VII, and ox brain extract. The abnormal constituent responsible for this inhibitor appears to be factor IX whuch is functionally inactive but antigenically indis...

A trial of prophylactic replacement therapy in haemophilia and Christmas disease.

A trial of prophylactic replacement therapy in low dosage once a week is described in two patients with classical haemophilia and one patient with Christmas disease, using concentrates of factor VIII and factor IX respectively. The clinical effectiveness and complications of the therapy are assessed and discussed. It was concluded that the patient suffering from Christmas disease showed both ob...

The management of fractures in haemophilia and Christmas disease.